Article
Molecular biology of amyotrophic lateral sclerosis: insights from genetics.
Nature reviews. Neuroscience - 1 Sept 2006
Pasinelli Piera, Brown Robert H
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a paralytic disorder caused by motor neuron degeneration. Mutations in more than 50 human genes cause diverse types of motor neuron pathology. Moreover, defects in five Mendelian genes lead to motor neuron disease, with two mutations reproducing the ALS phenotype. Analyses of these genetic effects have generated new insights into the diverse molecular pathways involved in...
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