Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic instability in primary leiomyosarcoma of bone.

Human pathology - 1 Nov 2004

Verelst Sven J G, Hans Joachim, Hanselmann Rainer G, Wirbel Reiner J

Abstract excerpt

Primary leiomyosarcoma (LMS) of bone is an exceedingly rare entity on which to date no molecular data have been reported. In a series of 6 tumors (5 grade IIB, 1 grade IIA), we assessed the prevailing genetic stability by microsatellite analysis at 7 loci. The IIB tumors demonstrated a rate of genomic loss as high as 90%, accompanied by an intratumoral heterogeneity in 30% of conspicuous markers. High...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms
Share to DNA, Neoplasm
Share to Genomic Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Leiomyosarcoma

Share to Loss of Heterozygosity

Share to MutS Homolog 2 Protein

Share to Neoplasm Staging

Source

Identifiers

PMID: 15668899
DOI: 10.1016/j.humpath.2004.06.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Genetic instability in primary leiomyosarcoma of bone.PMID 15668899Read ↗

Uterine leiomyoma cytogeneticsSemantic proximity Read ↗

Detection of K-ras mutations in resected primary leiomyosarcoma.Semantic proximity Read ↗

Characterization of chromosome aberrations associated with soft‐tissue leiomyosarcomas by twenty‐four‐color karyotyping and comparative genomic hybridization analysisSemantic proximity Read ↗

Frequent occurrence of loss of heterozygosity among tumor suppressor genes in uterine leiomyosarcoma.Semantic proximity Read ↗

p53 expression is decreased in primary breast carcinomas with microsatellite instability.Semantic proximity Read ↗

Molecular characterization and liposomal transfection of a p53-mutated cell line established from a poorly differentiated leiomyosarcoma.Semantic proximity Read ↗

Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor.Semantic proximity Read ↗

Genetic aberrations in soft tissue leiomyosarcoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.