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Article

Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase ( Btk ) loci.

1 Dec 1994

Abstract excerpt

Btk is a cytoplasmic protein tyrosine kinase (PTK) that has been directly implicated in the pathogenesis of X-linked agammaglobulinaemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. We have isolated phage and cosmid clones that allowed us to deduce the genomic structure of mouse and human Btk loci. The mouse and human genes are contained within genomic regions that span approximately 43.5 kb and...

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Identifiers

PMID: 7989760
DOI: 10.4049/jimmunol.153.12.5607

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Source receipt: pubmed, retrieved 7 Sept 2026.

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