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Article

Degradation of the HilC and HilD regulator proteins by ATP-dependent Lon protease leads to downregulation of Salmonella pathogenicity island 1 gene expression.

Molecular microbiology - 1 Feb 2005

Takaya Akiko, Kubota Yohsuke, Isogai Emiko, Yamamoto Tomoko

Abstract excerpt

Salmonella pathogenicity island 1 (SPI1) enables infecting Salmonella to cross the small intestinal barrier and to escape phagocytosis by inducing apoptosis. Several environmental signals and transcriptional regulators modulate the expression of hilA, which encodes a protein playing a central role in the regulatory hierarchy of SPI1 gene expression. We have previously shown that Lon, a stress-induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15661008
DOI: 10.1111/j.1365-2958.2004.04425.x

Genes

SPI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Degradation of the HilC and HilD regulator proteins by ATP-dependent Lon protease leads to downregulation of Salmonella pathogenicity island 1 gene expression.PMID 15661008Read ↗

The ATP-dependent lon protease of Salmonella enterica serovar Typhimurium regulates invasion and expression of genes carried on Salmonella pathogenicity island 1.Semantic proximity Read ↗

Lon Protease Activity Causes Down-Regulation of Salmonella Pathogenicity Island 1 Invasion Gene Expression after Infection of Epithelial CellsSemantic proximity Read ↗

Coordinated regulation of expression of Salmonella pathogenicity island 1 and flagellar type III secretion systems by ATP-dependent ClpXP protease.Semantic proximity Read ↗

Roles of hilC and hilD in regulation of hilA expression in Salmonella enterica serovar Typhimurium.Semantic proximity Read ↗

HilE Interacts with HilD and Negatively Regulates hilA Transcription and Expression of the Salmonella enterica Serovar Typhimurium Invasive PhenotypeSemantic proximity Read ↗

Two AraC/XylS family members can independently counteract the effect of repressing sequences upstream of the hilA promoter.Semantic proximity Read ↗

Derepression of Salmonella pathogenicity island 1 genes within macrophages leads to rapid apoptosis via caspase-1- and caspase-3-dependent pathways.Semantic proximity Read ↗

AraC/XylS family members, HilD and HilC, directly activate virulence gene expression independently of HilA in Salmonella typhimuriumSemantic proximity Read ↗

The HilA Box and Sequences outside It Determine the Magnitude of HilA-Dependent Activation of P prgH from Salmonella Pathogenicity Island 1Semantic proximity Read ↗

HilE Regulates HilD by Blocking DNA Binding in Salmonella enterica Serovar Typhimurium.Semantic proximity Read ↗

Transcription of theSalmonellaInvasion Gene Activator,hilA, Requires HilD Activation in the Absence of Negative RegulatorsSemantic proximity Read ↗

An incoherent feedforward loop formed by SirA/BarA, HilE and HilD is involved in controlling the growth cost of virulence factor expression by Salmonella Typhimurium.Semantic proximity Read ↗

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