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Article

HilE Regulates HilD by Blocking DNA Binding in Salmonella enterica Serovar Typhimurium.

Journal of bacteriology - 15 Apr 2018

Grenz Jesse R, Cott Chubiz Jessica E, Thaprawat Pariyamon, Slauch James M

Abstract excerpt

The Salmonella type three secretion system (T3SS), encoded in the Salmonella pathogenicity island 1 (SPI1) locus, mediates the invasion of the host intestinal epithelium. SPI1 expression is dependent upon three AraC-like regulators: HilD, HilC, and RtsA. These regulators act in a complex feed-forward loop to activate each other and hilA, which encodes the activator of the T3SS structural genes. HilD has been...

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Source

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Identifiers

PMID: 29378886
DOI: 10.1128/JB.00750-17
PMCID: PMC5869468

Genes

SPI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HilE Regulates HilD by Blocking DNA Binding in Salmonella enterica Serovar Typhimurium.PMID 29378886Read ↗

Transcription of theSalmonellaInvasion Gene Activator,hilA, Requires HilD Activation in the Absence of Negative RegulatorsSemantic proximity Read ↗

HilE Interacts with HilD and Negatively Regulates hilA Transcription and Expression of the Salmonella enterica Serovar Typhimurium Invasive PhenotypeSemantic proximity Read ↗

Two AraC/XylS family members can independently counteract the effect of repressing sequences upstream of the hilA promoter.Semantic proximity Read ↗

AraC/XylS family members, HilD and HilC, directly activate virulence gene expression independently of HilA in Salmonella typhimuriumSemantic proximity Read ↗

Roles of hilC and hilD in regulation of hilA expression in Salmonella enterica serovar Typhimurium.Semantic proximity Read ↗

HilD, HilC, and RtsA Form Homodimers and Heterodimers To Regulate Expression of the Salmonella Pathogenicity Island I Type III Secretion SystemSemantic proximity Read ↗

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An incoherent feedforward loop formed by SirA/BarA, HilE and HilD is involved in controlling the growth cost of virulence factor expression by Salmonella Typhimurium.Semantic proximity Read ↗

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