Article
An incoherent feedforward loop formed by SirA/BarA, HilE and HilD is involved in controlling the growth cost of virulence factor expression by Salmonella Typhimurium.
PLoS pathogens - 1 May 2021
Pérez-Morales Deyanira, Nava-Galeana Jessica, Rosales-Reyes Roberto, Teehan Paige, Yakhnin Helen, Melchy-Pérez Erika I, Rosenstein Yvonne, De la Cruz Miguel A, Babitzke Paul, Bustamante Víctor H
Abstract excerpt
An intricate regulatory network controls the expression of Salmonella virulence genes. The transcriptional regulator HilD plays a central role in this network by controlling the expression of tens of genes mainly required for intestinal colonization. Accordingly, the expression/activity of HilD is highly regulated by multiple factors, such as the SirA/BarA two-component system and the Hcp-like protein HilE....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.