Article
Identification of a naturally occurring transforming variant of the p65 subunit of NF-kappa B.
Science (New York, N.Y.) - 17 Apr 1992
Narayanan R, Klement J F, Ruben S M, Higgins K A, Rosen C A
Abstract excerpt
Transcription factor NF-kappa B comprises two proteins, p50 and p65, that have sequence similarity to the v-rel oncogene. In primary hematopoietic cell populations an alternatively spliced form of NF-kappa B p65 mRNA was observed that encoded a protein designated p65 delta. Expression of the p65...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Transformation, Neoplastic
- DNA
- Fibroblasts
- Genetic Variation
- Hematopoietic Stem Cells
- Humans
- Mice
- Mice, Nude
- Molecular Sequence Data
- NF-kappa B
- Neoplasm Transplantation
- Oncogene Proteins v-rel
- Polymerase Chain Reaction
- RNA Splicing
- RNA, Messenger