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Article

How Stress and Fluoxetine Modulate Serotonin 2C Receptor Pre-mRNA Editing

19 Jan 2005

Abstract excerpt

In two inbred strains of mice, C57BL/6 and 129Sv, the majority of forebrain neocortical pre-mRNA encoding the serotonin 2C (5-HT2C) receptor is altered by adenosine-to-inosine editing. As a result, >60% of all mRNAs encode receptors with reduced constitutive and agonist-stimulated activity. However, in the BALB/c strain, a genetically distinct inbred strain with lower forebrain serotonin levels, spontaneously...

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PMID: 15659601
DOI: 10.1523/jneurosci.3895-04.2005

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