Article
No link of serotonin 2C receptor editing to serotonin transporter genotype.
Neuroreport - 8 Dec 2010
Lyddon Rebecca, Cuppen Edwin, Haroutunian Vahram, Siever Larry J, Dracheva Stella
Abstract excerpt
RNA editing is a post-transcriptional process, which has the potential to alter the function of encoded proteins. In particular, serotonin 2C receptor (5-HT2cR) mRNA editing can produce 24 protein isoforms of varying functionality. Rodent studies have shown that 5-HT2cR editing is dynamically modulated in response to environmental challenges. Basal extracellular serotonin, which is strongly influenced by...
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