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Article

A-to-I editing of the 5HT2C receptor and behaviour

21 Feb 2006

Abstract excerpt

Site-specific deamination of five adenosine residues in the pre-mRNA of the serotonin 2C receptor, 5HT2CR, alters the amino acid sequence of the encoded protein. Such RNA editing can produce 32 mRNA variants, encoding 24 protein isoforms that vary in biochemical and pharmacological properties. Because serotonin functions in the regulation of mood and behaviour, modulation of serotonin signalling by RNA editing...

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PMID: 16769676
DOI: 10.1093/bfgp/ell006

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