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Article

Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activation.

PLoS computational biology - 1 Nov 2011

Narayanan Arjun, LeClaire Lawrence L, Barber Diane L, Jacobson Matthew P

Abstract excerpt

Actin filament assembly by the actin-related protein (Arp) 2/3 complex is necessary to build many cellular structures, including lamellipodia at the leading edge of motile cells and phagocytic cups, and to move endosomes and intracellular pathogens. The crucial role of the Arp2/3 complex in cellular processes requires precise spatiotemporal regulation of its activity. While binding of nucleation-promoting factors...

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Share to Actin Cytoskeleton
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22125478
DOI: 10.1371/journal.pcbi.1002226
PMCID: PMC3220268

Genes

ARPC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activation.PMID 22125478Read ↗

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