Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct role for c-kit receptor tyrosine kinase and SgIGSF adhesion molecule in attachment of mast cells to fibroblasts.

Laboratory investigation; a journal of technical methods and pathology - 1 Mar 2005

Koma Yu-ichiro, Ito Akihiko, Watabe Kenji, Hirata Tatsumi, Mizuki Masao, Yokozaki Hiroshi, Kitamura Toshio, Kanakura Yuzuru, Kitamura Yukihiko

Abstract excerpt

Binding of stem cell factor (SCF) to c-kit receptor tyrosine kinase (KIT) transduces signals essential for mast cell development via several pathways including activation of phosphatidylinositol 3-kinase (PI3-K). When cultured mast cells (CMCs) are cocultured with fibroblasts expressing membrane-bound SCF, CMCs with normal KIT adhere to fibroblasts and proliferate, whereas CMCs lacking cell surface expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mast Cells
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Adhesion Molecules

Share to Coculture Techniques

Share to Immunoglobulins

Share to NIH 3T3 Cells

Share to Proto-Oncogene Proteins c-kit

Share to Stem Cell Factor

Source

Identifiers

PMID: 15654360
DOI: 10.1038/labinvest.3700231

Genes

KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Distinct role for c-kit receptor tyrosine kinase and SgIGSF adhesion molecule in attachment of mast cells to fibroblasts.PMID 15654360Read ↗

Contribution of the SgIGSF adhesion molecule to survival of cultured mast cells in vivo.Semantic proximity Read ↗

SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF.Semantic proximity Read ↗

Distinct roles for the SgIGSF adhesion molecule and c-kit receptor tyrosine kinase in the interaction between mast cells and the mesentery.Semantic proximity Read ↗

Low c-kit expression of cultured mast cells of mi/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit.Semantic proximity Read ↗

Necessity of extracellular domain of W (c-kit) receptors for attachment of murine cultured mast cells to fibroblasts.Semantic proximity Read ↗

Number of mast cells in the peritoneal cavity of mice: influence of microphthalmia transcription factor through transcription of newly found mast cell adhesion molecule, spermatogenic immunoglobulin superfamily.Semantic proximity Read ↗

Regulation of mast cell phenotype by MITF.Semantic proximity Read ↗

Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of miceSemantic proximity Read ↗

Adhesion of mouse mast cells to fibroblasts: adverse effects of steel (Sl) mutation.Semantic proximity Read ↗

Expression of immunoglobulin superfamily cell adhesion molecules on murine embryonic stem cells.Semantic proximity Read ↗

Binding of germ cells to mutant Sld Sertoli cells is defective and is rescued by expression of the transmembrane form of the c-kit ligand.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.