Article
Genetic disorders involving molecular-chaperone genes: a perspective.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2005
Macario Alberto J L, Grippo Tomas M, Conway de Macario Everly
Abstract excerpt
Molecular chaperones are important for maintaining a functional set of proteins in all cellular compartments. Together with protein degradation machineries (e.g., the ubiquitin-proteasome system), chaperones form the core of the cellular protein-quality control mechanism. Chaperones are proteins, and as such, they can be affected by mutations. At least 15 disorders have been identified that are associated with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.