Article
Chaperone overload is a possible contributor to 'civilization diseases'.
Trends in genetics : TIG - 1 Dec 2001
Csermely P
Abstract excerpt
Molecular chaperones dampen the effect of damaging mutations that would otherwise be removed from the population by natural selection. Here, I propose that the development of modern medical practice depressed this process, leading to a rise of phenotypically silent mutations in the genome. The background of misfolded proteins increases during ageing and, by competition, prevents the chaperone-mediated buffering...
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