Article
The role of IL-1 gene cluster in longevity: a study in Italian population.
Mechanisms of ageing and development - 1 Apr 2003
Cavallone Luca, Bonafè Massimiliano, Olivieri Fabiola, Cardelli Maurizio, Marchegiani Francesca, Giovagnetti Simona, Di Stasio Grazia, Giampieri Claudia, Mugianesi Elena, Stecconi Rosalia, Sciacca Francesca, Grimaldi Luigi Maria, De Benedictis Giovanna, Lio Domenico, Caruso Calogero, Franceschi Claudio
Abstract excerpt
In this study, we analysed the polymorphic variants of IL-1alpha (C-T transition at position -889), IL-1beta (C-T transition at position -511) and IL-1 receptor antagonist (Ra) (86-bp repeated sequence in intron 2) in 1131 subjects (453 females and 678 males) from Northern and Central Italy, including 134 centenarians, to evaluate whether IL-1 cluster alleles might be differently represented in people selected...
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