Article
Regulation of cardiac hypertrophy by intracellular signalling pathways.
Nature reviews. Molecular cell biology - 1 Aug 2006
Heineke Joerg, Molkentin Jeffery D
Abstract excerpt
The mammalian heart is a dynamic organ that can grow and change to accommodate alterations in its workload. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes. Recent findings in genetically modified animal models implicate important intermediate...
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