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Article

Altered Expression of Insulin Receptor Isoforms in Breast Cancer

26 Oct 2011

Abstract excerpt

PURPOSE: Insulin-like growth factor (IGF) signaling through human insulin receptor isoform A (IR-A) contributes to tumorigenesis and intrinsic resistance to anti-IGF1R therapy. In the present study, we (a) developed quantitative TaqMan real time-PCR-based assays (qRT-PCR) to measure human insulin receptor isoforms with high specificity, (b) evaluated isoform expression levels in molecularly-defined breast cancer...

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PMID: 22046260
DOI: 10.1371/journal.pone.0026177

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