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Article

Short-term regulation of multidrug resistance-associated protein 3 in rat and human hepatocytes

14 Jan 2005

Abstract excerpt

The short-term regulation of multidrug resistance-associated protein 3 (Mrp3/MRP3) by cAMP and PKC was investigated in sandwich-cultured rat and human hepatocytes and isolated perfused rat livers. The modulator glucagon (500 nM) and the phorbol ester PMA (0.1 muM) were utilized to increase intracellular cAMP and PKC levels, respectively. In glucagon-treated rat hepatocytes, efflux of the Mrp3 substrate...

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Identifiers

PMID: 15650133
DOI: 10.1152/ajpgi.00362.2004

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