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Article

Influence of IL-6 on MDR and MRP-mediated multidrug resistance in human hepatoma cells

1 Oct 2001

Abstract excerpt

The objective of this study was to examine effects of interleukin-6 (IL-6) on the expression and activity of the drug resistance transporters (MDR1 and MRP) in human hepatoma cell lines. Expression and activity of MDR1 and MRP transporters were examined in IL-6-treated and control HuH 7 and HepG2 cells using semi-quantitative RT-PCR analysis and by rhodamine 123 and 5-carboxyfluorescin efflux assays. Results from...

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PMID: 11697747
DOI: 10.1139/y01-071

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