Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture.

Biochemical pharmacology - 1 Nov 2011

Ulvestad Maria, Björquist Petter, Molden Espen, Asberg Anders, Andersson Tommy B

Abstract excerpt

Primary human hepatocytes are widely used as an in vitro model for evaluation of drug metabolism and transport. However, it has been shown that the gene expression of many drug-metabolizing enzymes and transporters change in culture. The aim of the present study was to evaluate the activity of organic anion-transporting polypeptide 1B1 (OATP1B1) and 1B3 (OATP1B3) in plated primary human hepatocytes over time in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Estradiol
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Liver-Specific Organic Anion Transporter 1

Share to Organic Anion Transporters

Share to Organic Anion Transporters, Sodium-Independent

Share to Solute Carrier Organic Anion Transporter Family Member 1B3

Source

Identifiers

PMID: 21787759
DOI: 10.1016/j.bcp.2011.07.076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture.PMID 21787759Read ↗

Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity StudiesSemantic proximity Read ↗

Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver InjurySemantic proximity Read ↗

Comparative analysis of 3D and 2D in vitro models of the permanent fish liver cell line RTL-W1: Metabolic capabilities and responses to xenobioticsSemantic proximity Read ↗

Cell Lines: A Tool for In Vitro Drug Metabolism StudiesSemantic proximity Read ↗

Cell-based models to study hepatic drug metabolism and enzyme induction in humansSemantic proximity Read ↗

An update on metabolism studies using human hepatocytes in primary cultureSemantic proximity Read ↗

Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicitySemantic proximity Read ↗

Influence of culture time on the expression of drug‐metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2Semantic proximity Read ↗

Micropatterned Co-Cultures of Human Hepatocytes and Stromal Cells for the Assessment of Drug Clearance and Drug-Drug Interactions.Semantic proximity Read ↗

The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in humanSemantic proximity Read ↗

Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 daysSemantic proximity Read ↗

A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized liversSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.