Article
[Treatment with a tyrosine-kinase inhibitor of for c-KIT mutation and AML1-ETO double positive refractory acute myeloid leukemia].
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Apr 2012
Ueyama Jun-Ichi, Kure Akira, Okuno Keisuke, Sano Hitoshi, Tamoto Naohiro, Kanzaki Susumu
Abstract excerpt
Translocation (8;21)/AML1-ETO is considered a favorable cytogenetic abnormality in acute myeloid leukemia (AML). However, the outcomes associated with KIT mutations in AML1-ETO have not been elucidated. A 16-year-old boy was diagnosed with recurrent AML. Although he underwent hematopoietic stem cell transplantation (HSCT) twice, the leukemia relapsed and grew resistant to several chemotherapies. We began to treat...
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