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Article

Do morphogen gradients arise by diffusion?

Developmental cell - 1 Jun 2002

Lander Arthur D, Nie Qing, Wan Frederic Y M

Abstract excerpt

Many patterns of cell and tissue organization are specified during development by gradients of morphogens, substances that assign different cell fates at different concentrations. Gradients form by morphogen transport from a localized site, but whether this occurs by simple diffusion or by more elaborate mechanisms is unclear. We attempt to resolve this controversy by analyzing recent data in ways that...

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PMID: 12062090
DOI: 10.1016/s1534-5807(02)00179-x

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