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Article

Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands

13 Jan 2005

Abstract excerpt

It has been postulated that the stem cells of somatic tissues protect themselves from mutation and cancer risk by selective segregation of their template DNA strands. Self-renewing mammary epithelial stem cells that were originated during allometric growth of the mammary ducts in pubertal females were labeled using [3H]-thymidine (3HTdR). After a prolonged chase during which much of the branching duct...

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PMID: 15647322
DOI: 10.1242/dev.01609

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