Article
In vivo dynamics of the 103N mutation following the withdrawal of non-nucleoside reverse transcriptase inhibitors in HIV-infected patients: preliminary results.
The new microbiologica - 1 Apr 2004
Gianotti N, Boeri E, Maillard M, Serra G, Ratti D, Gallotta G, Vacchini D, Tremolada Y, Castagna A
Abstract excerpt
Due to the preferential selection of the fittest HIV mutants, drug-resistant variants are often overgrown by wild-type virus after treatment interruption. Our objective was to investigate the dynamics of the 103N mutation (which usually does not reduce HIV fitness) following the withdrawal of non-nucleoside reverse transcriptase inhibitors (NNRTIs). Patients who were found to have the 103N mutation at or after...
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