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Article

Human papillomavirus 16 E6 increases the radiosensitivity of p53-mutated cervical cancer cells, associated with up-regulation of aurora A.

International journal of radiation biology - 1 Sept 2010

Shin Hye-Jin, Kim Joo-Young, Hampson Lynne, Pyo Hongryull, Baek Hye Jung, Roberts Stephen A, Hendry Jolyon H, Hampson Ian N

Abstract excerpt

PURPOSE: To examine the effect of the human papillomavirus (HPV) type 16-E6 (HPV 'early' gene) oncoprotein on in vitro radiosensitivity of HPV-negative/p53 mutant C33a cervical cancer cells. METHODS AND MATERIALS: The human cervical cancer cell line C33a was stably transfected with either the HPV16 E6 cDNA cloned into the vector pcDNA3.0 (C33aE6) or the empty-vector control (C33aV). Radiosensitivity, DNA damage,...

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Share to Aurora Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20670113
DOI: 10.3109/09553002.2010.484477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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