Article
Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis.
Cell death and differentiation - 1 Dec 2010
Lassot I, Robbins I, Kristiansen M, Rahmeh R, Jaudon F, Magiera M M, Mora S, Vanhille L, Lipkin A, Pettmann B, Ham J, Desagher S
Abstract excerpt
Accumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical E3 ubiquitin ligases involved in the control of neuronal apoptosis upstream of mitochondria. We show that expression of Trim17 is increased both at the mRNA and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.