Trypanosoma cruzi trans‐sialidase induces STAT3 and ERK activation by prokineticin receptor 2 binding

Abstract excerpt

Abstract Tc85, as other members of trans‐sialidase family, is involved in Trypanosoma cruzi parasite adhesion to mammalian cells. Particularly, Tc85 acts through specific interactions with prokineticin receptor 2, a G‐protein coupled receptor involved in diverse physiological and pathological processes. In this manuscript, through biochemical analyses, we demonstrated that LamG, a Tc85 domain, physically...

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