Functional analysis of the first mannosyltransferase (PIG-M) involved in glycosylphosphatidylinositol synthesis in Plasmodium falciparum.

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Article

Functional analysis of the first mannosyltransferase (PIG-M) involved in glycosylphosphatidylinositol synthesis in Plasmodium falciparum.

Molecules and cells - 31 Oct 2007

Kim Youn Uck, Hong Yeongjin

Abstract excerpt

The mammalian glycosylphosphatidylinositol (GPI) anchor consists of three mannoses attached to acylated GlcN-(acyl)PI to form Man(3)-GlcN-(acyl)PI. The first of the three mannose groups is attached to an intermediate to generate Man-GlcN-(acyl)PI by the first mannosyltransferase (GPI-MT-I). Mammalian and protozoan GPI-MT-I have different substrate specificities. PIG-M encodes the mammalial GPI-MT-I which has 423...

Topics

Amino Acid Sequence
Animals
Cloning, Molecular
Flow Cytometry
Glycosylphosphatidylinositols
Humans
Mannosyltransferases
Molecular Sequence Data
Mutation
Plasmodium falciparum
Saccharomyces cerevisiae
Sequence Alignment
Transfection

Source

Open in PubMed

Identifiers

PMID: 17978585

Genes

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