Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition.

The Journal of biological chemistry - 18 Mar 2005

Woodring Pamela J, Hunter Tony, Wang Jean Y J

Abstract excerpt

We have previously shown that F-actin exerts a negative effect on Abl tyrosine kinase activity. This inhibition results from a direct association of F-actin with the C terminus of Abl and accounts, in part, for the loss of Abl activity in detached fibroblasts. We report here that Abl from mitotic cells or cells treated with the protein phosphatase inhibitor okadaic acid remains active when detached from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Site
Share to NIH 3T3 Cells
Share to Okadaic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymers

Share to Proto-Oncogene Proteins c-abl

Share to RNA Polymerase II

Share to src Homology Domains

Share to Trypsin

Source

Identifiers

PMID: 15632178
DOI: 10.1074/jbc.M410658200

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition.PMID 15632178Read ↗

Abelson kinase's intrinsically disordered region plays essential roles in protein function and protein stability.Semantic proximity Read ↗

Structure and dynamic regulation of Abl kinases.Semantic proximity Read ↗

Deletion of the Src Homology 3 Domain and C-terminal Proline-rich Sequences in Bcr-Abl Prevents Abl Interactor 2 Degradation and Spontaneous Cell Migration and Impairs LeukemogenesisSemantic proximity Read ↗

Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp.Semantic proximity Read ↗

Abl regulates planar polarized junctional dynamics through β-catenin tyrosine phosphorylation.Semantic proximity Read ↗

The CRKL Adaptor Protein Transforms Fibroblasts and Functions in Transformation by the BCR-ABL OncogeneSemantic proximity Read ↗

Abl kinase but not PI3-kinase links to the cytoskeletal defects in Bcr-Abl transformed cells.Semantic proximity Read ↗

Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL.Semantic proximity Read ↗

Autoinhibition of Bcr-Abl through its SH3 domain.Semantic proximity Read ↗

Phosphorylation of GMFγ by c-Abl coordinates lamellipodial and focal adhesion dynamicsSemantic proximity Read ↗

Structural Basis for the Cytoskeletal Association of Bcr-Abl/c-AblSemantic proximity Read ↗

Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.