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Article

Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML development

10 Jun 2003

Abstract excerpt

We have previously found that P210BCR-ABL increases the adhesion of hematopoietic cell lines to fibronectin by a mechanism that is independent of tyrosine kinase activity. To investigate the pathway(s) by which P210BCR-ABL influences cell adhesion, we used a quantitative cell adhesion device that can discern small changes in cell adhesion to assay P210BCR-ABL with mutations in several critical domains. We...

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PMID: 12791659
DOI: 10.1182/blood-2003-01-0062

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