Article
Applying a new generation of genetic maps to understand human inflammatory disease.
Nature reviews. Immunology - 1 Jan 2005
Hafler David A, De Jager Philip L
Abstract excerpt
The sequencing of the human genome and the intense study of its variation in different human populations have improved our understanding of the genome's architecture. It is now becoming clear that segments of the genome that are unbroken by reshuffling or recombination during meiosis create a mosaic of DNA 'haplotype blocks'. Here, we discuss the advantages and limitations of this block structure. Haplotype...
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