Starvation for His-tRNAHis in yeast causes translational arrest without a high level of misincorporation of glutamine at histidine codons.

doi:10.1007/BF00336838

Back to search

Article

Starvation for His-tRNAHis in yeast causes translational arrest without a high level of misincorporation of glutamine at histidine codons.

Current genetics - 1 Mar 1992

Hirst K, Piper P W

Abstract excerpt

The hts1.1 temperature-sensitive histidinyl-tRNA synthetase mutation enables Saccharomyces cerevisiae to be starved for His-tRNAHis by upshift to the non-permissive temperature of 38 degrees C. If yeast behaves similarly to bacterial and mammalian cells, this lack of His-tRNAHis should greatly en...

Topics

Codon
Glutamine
Histidine
Histidine-tRNA Ligase
Mutation
Phosphoglycerate Kinase
Polyribosomes
Protein Biosynthesis
RNA, Transfer, Amino Acyl
RNA, Transfer, His
Saccharomyces cerevisiae
Temperature

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.