Article
Single nucleotide polymorphisms as a prerequisite for autoantigens.
European journal of immunology - 1 Feb 2005
Stadler Michael B, Arnold Diana, Frieden Sara, Luginbühl Sarah, Stadler Beda M
Abstract excerpt
It is still elusive why certain self proteins induce an autoimmune response. One immunological hypothesis is that only modified or altered self-proteins may become a target. Thus, we asked whether such alterations may actually be genetic polymorphisms that can be revealed by analyzing sequence variability in the known human autoantigens. Indeed, we found autoantigens to contain significantly more single...
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