Article
The association of CD81 polymorphisms with alloimmunization in sickle cell disease.
Clinical & developmental immunology - 1 Jan 2013
Tatari-Calderone Zohreh, Tamouza Ryad, Le Bouder Gama P, Dewan Ramita, Luban Naomi L C, Lasserre Jacqueline, Maury Jacqueline, Lionnet François, Krishnamoorthy Rajagopal, Girot Robert, Vukmanovic Stanislav
Abstract excerpt
The goal of the present work was to identify the candidate genetic markers predictive of alloimmunization in sickle cell disease (SCD). Red blood cell (RBC) transfusion is indicated for acute treatment, prevention, and abrogation of some complications of SCD. A well-known consequence of multiple RBC transfusions is alloimmunization. Given that a subset of SCD patients develop multiple RBC allo-/autoantibodies,...
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