Article
Polarized production of T-helper cell type 1 cells in Peyer's patches in Crohn's disease.
Digestion - 1 Jan 2004
Kudo Takahiro, Nagata Satoru, Aoyagi Yo, Suzuki Ryuyo, Matsuda Hironori, Ohtsuka Yoshikazu, Shimizu Toshiaki, Okumura Ko, Yamashiro Yuichiro
Abstract excerpt
BACKGROUND/AIMS: Although Peyer's patches (PPs) serve as important antigen-sampling sites for the immune system, surprisingly little attention has been paid to their associations with the onset of Crohn's disease (CD) as antigen entry sites. To examine the immunological events in PPs, we performed functional and phenotypical studies on PP cells, the lamina propria cells in the colonic mucosa and peripheral blood...
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