Article
Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models.
Pediatric research - 1 Jan 2008
Weiner Scott A, Caputo Christina, Bruscia Emanuela, Ferreira Elisa C, Price Joanna E, Krause Diane S, Egan Marie E
Abstract excerpt
Cystic fibrosis (CF) is an autosomal recessive disease that results from mutations in the CF transmembrane conductance regulator (CFTR) gene. The effect of interventions aimed at correcting the CF electrophysiologic phenotype has been primarily measured using in vitro methods in gastrointestinal and respiratory epithelia. A reliable in vivo assay of CFTR function would be of great value in the investigation of...
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