Article
Very mild disease phenotype of congenic CftrTgH(neoim)Hgu cystic fibrosis mice.
BMC genetics - 9 Apr 2008
Tóth Balázs, Wilke Martina, Stanke Frauke, Dorsch Martina, Jansen Silke, Wedekind Dirk, Charizopoulou Nikoletta, Bot Alice, Burmester Marion, Leonhard-Marek Sabine, de Jonge Hugo R, Hedrich Hans-Jürgen, Breves Gerhard, Tümmler Burkhard
Abstract excerpt
BACKGROUND: A major boost to cystic fibrosis disease research was given by the generation of various mouse models using gene targeting in embryonal stem cells. Moreover, the introduction of the same mutation on different inbred strains generating congenic strains facilitated the search for modifier genes. From the original CftrTgH(neoim)Hgu mouse model with a divergent genetic background (129/Sv, C57BL/6,...
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