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Article

Alternate mechanisms of initial pattern recognition drive differential immune responses to related poxviruses.

Cell host & microbe - 19 Aug 2010

O'Gorman William E, Sampath Padma, Simonds Erin F, Sikorski Rachel, O'Malley Mark, Krutzik Peter O, Chen Hannah, Panchanathan Vijay, Chaudhri Geeta, Karupiah Gunasegaran, Lewis David B, Thorne Steve H, Nolan Garry P

Abstract excerpt

Vaccinia immunization was pivotal to successful smallpox eradication. However, the early immune responses that distinguish poxvirus immunization from pathogenic infection remain unknown. To address this, we developed a strategy to map the activation of key signaling networks in vivo and applied t...

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Identifiers

PMID: 20709294
DOI: 10.1016/j.chom.2010.07.008
PMCID: PMC2940993

Genes

STAT3
TLR2
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20709294-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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