Article
Restoring the apoptosis suppression response to IL-5 confers on erythroleukemic cells a phenotype of IL-5-dependent growth.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1995
Yen J J, Hsieh Y C, Yen C L, Chang C C, Lin S, Yang-Yen H F
Abstract excerpt
We have established a human IL-5 (hIL-5) dependent cell line, JYTF-1, derived from TF-1 parental human erythroleukemic cells by long-term cultivation in the presence of hIL-5. The ED50 values of hIL-5 for both TF-1 and JYTF-1 cell lines remained similar. However, when cells were grown in an optim...
Topics
- Apoptosis
- Base Sequence
- Cell Division
- DNA Primers
- DNA, Neoplasm
- Gene Expression
- Humans
- Interleukin-5
- Leukemia, Erythroblastic, Acute
- Molecular Sequence Data
- Phenotype
- Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
- Receptors, Interleukin
- Receptors, Interleukin-5
- Thymidine
- Tumor Cells, Cultured