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Article

Role of the degree of oligomerization in the structure and function of human surfactant protein A.

The Journal of biological chemistry - 4 Mar 2005

Sánchez-Barbero Fernando, Strassner Jochen, García-Cañero Rafael, Steinhilber Wolfram, Casals Cristina

Abstract excerpt

The role of the degree of oligomerization in the structure and function of human surfactant protein A (SP-A) was investigated using a human SP-A1 mutant (SP-A1(DeltaAVC,C6S)), expressed in mammalian cells, resulting from site-directed substitution of serine for Cys(6) and substitution of a functional signal peptide for the cysteine-containing SP-A signal sequence. This Cys(6) mutant lacked the NH(2)-terminal...

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PMID: 15615713
DOI: 10.1074/jbc.M410266200

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