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Article

Assembly of the surfactant protein SP-A. Deletions in the globular domain interfere with the correct folding of the molecule.

European journal of biochemistry - 1 Jul 1991

Spissinger T, Schäfer K P, Voss T

Abstract excerpt

The C-terminal non-collagenous domain of the surfactant glycoprotein SP-A was shown to be essential for its correct folding and assembly, as judged by the secretion of various deletion mutants transiently expressed in COS cells. A deletion mutant coding for this domain was successfully secreted while the expression of the collagenous domain only did not lead to any detectable secretion. Deletion mutants lacking...

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PMID: 1712301
DOI: 10.1111/j.1432-1033.1991.tb16092.x

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