Article
NAD(P)H: quinone oxidoreductase (NQO1) gene polymorphism and schizophrenia.
Psychiatry research - 15 Jun 2003
Hori Hiroko, Ohmori Osamu, Matsumoto Chima, Shinkai Takahiro, Nakamura Jun
Abstract excerpt
NAD(P)H: quinone oxidoreductase (NQO1), an obligate two-electron reductase of quinones, prevents their participation in redox cycling and subsequent generation of reactive oxygen species (ROS). Reduced or negative activity of NQO1 would lead to an excess of neurotoxic compounds of cathecolamine o-quinones and ROS. Recently, there has been increasing evidence that catecholamine o-quinones and ROS might contribute...
Topics
- Adult
- Cross-Sectional Studies
- Female
- Genotype
- Humans
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
- Oxidation-Reduction
- Polymorphism, Genetic
- Schizophrenia