Article
The increased activity of plasma manganese superoxide dismutase in tardive dyskinesia is unrelated to the Ala-9Val polymorphism.
Journal of psychiatric research - 1 Jan 2000
Zhang ZhiJun, Zhang XiaoBin, Hou Gang, Sha WeiWei, Reynolds Gavin P
Abstract excerpt
That tardive dyskinesia (TD) may have its origins in free-radical toxicity has stimulated investigations into one enzyme important in the control of oxidative free radicals: superoxide dismutase (SOD). The manganese-containing form of this enzyme (MnSOD) is the major superoxide scavenger in mitochondria; a weak association between a functional genetic polymorphism (Ala-9Val) in the mitochondrial targeting...
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