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Article

Mutant huntingtin affects the rate of transcription of striatum-specific isoforms of phosphodiesterase 10A.

The European journal of neuroscience - 1 Dec 2004

Hu Haibei, McCaw Elizabeth A, Hebb Andrea L O, Gomez Geraldine T, Denovan-Wright Eileen M

Abstract excerpt

Huntington's disease (HD) is caused by the inheritance of a copy of the gene encoding mutant huntingtin with an expanded CAG repeat. Phosphodiesterase 10A (PDE10A) mRNA decreases in transgenic HD mice expressing exon 1 of the human huntingtin gene (HD). The mouse PDE10A mRNA is expressed through alternative splicing and polyadenylation in a tissue-specific manner and that transcription of striatal PDE10A mRNA is...

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PMID: 15610167
DOI: 10.1111/j.1460-9568.2004.03796.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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