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Article

Novel PDE10A transcript diversity in the human striatum: Insights into gene complexity, conservation and regulation.

Gene - 30 Mar 2017

MacMullen Courtney M, Fallahi Mohammad, Davis Ronald L

Abstract excerpt

PDE10A is a cAMP/cGMP phosphodiesterase important in signal transduction within medium spiny neurons of the human striatum. This gene region has been associated with bipolar disorder via case-control and linkage studies. The three most studied human PDE10A isoforms differ in both their N-termini and trafficking within the cell with PDE10A2 found predominantly at the plasma membrane and PDE10A1 and PDE10A19...

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Identifiers

PMID: 28042091
DOI: 10.1016/j.gene.2016.12.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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