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Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain

1 Jan 2013

Abstract excerpt

BACKGROUND: Huntington's disease is caused by expansion of CAG trinucleotide repeats in the first exon of the huntingtin gene, which is essential for both development and neurogenesis. Huntington's disease is autosomal dominant. The normal allele contains 6 to 35 CAG triplets (average, 18) and the mutant, disease-causing allele contains >36 CAG triplets (average, 42). OBJECTIVE: We examined 279 postmortem brain...

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PMID: 25062733
DOI: 10.3233/jhd-130079

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