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Article

beta-catenin (CTNNB1) gene amplification: a new mechanism of protein overexpression in cancer.

Genes, chromosomes & cancer - 1 Mar 2005

Suriano Gianpaolo, Vrcelj Nikoleta, Senz Janine, Ferreira Paulo, Masoudi Hamid, Cox Kelley, Nabais Sergio, Lopes Carlos, Machado José Carlos, Seruca Raquel, Carneiro Fatima, Huntsman David G

Abstract excerpt

beta-Catenin nuclear translocation is frequently observed in different types of malignancies, including gastric cancer. In gastric cancer, however, the molecular mechanisms leading to accumulation of this protein in the nucleus remain unknown. In this setting, beta-catenin (CTNNB1) mutations have been reported, but studies of mutation frequency have yielded conflicting results. Mutations or silencing of other...

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Source

Identifiers

PMID: 15609344
DOI: 10.1002/gcc.20135

Genes

CTNNB1
APC
CCND1
WNT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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