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An Icelandic example of the impact of population structure on association studies.

Nature genetics - 1 Jan 2005

Helgason Agnar, Yngvadóttir Bryndís, Hrafnkelsson Birgir, Gulcher Jeffrey, Stefánsson Kári

Abstract excerpt

The impact of population structure on association studies undertaken to identify genetic variants underlying common human diseases is an issue of growing interest. Spurious associations of alleles with disease phenotypes may be obtained or true associations overlooked when allele frequencies differ notably among subpopulations that are not represented equally among cases and controls. Population structure...

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PMID: 15608637
DOI: 10.1038/ng1492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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