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Article

A Human Telomeric Protein

8 Dec 1995

Abstract excerpt

Telomeres are multifunctional elements that shield chromosome ends from degradation and end-to-end fusions, prevent activation of DNA damage checkpoints, and modulate the maintenance of telomeric DNA by telomerase. A major protein component of human telomeres has been identified and cloned. This factor, TRF, contains one Myb-type DNA-binding repeat and an amino-terminal acidic domain. Immunofluorescent labeling...

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Share to Advanced biosensing and bioanalysis techniques
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7502076
DOI: 10.1126/science.270.5242.1663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Human Telomeric ProteinPMID 7502076Read ↗

Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2Semantic proximity Read ↗

The Human Telomeric Protein TRF1 Specifically Recognizes Nucleosomal Binding Sites and Alters Nucleosome StructureSemantic proximity Read ↗

Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domainsSemantic proximity Read ↗

How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high‐resolution crystal structuresSemantic proximity Read ↗

Sequence-specific DNA recognition by the Myb-like domain of the human telomere binding protein TRF1: A model for the protein-DNA complexSemantic proximity Read ↗

Importance of TRF1 for functional telomere structure.Semantic proximity Read ↗

Telomeric localization of TRF2, a novel human telobox proteinSemantic proximity Read ↗

Identification and characterization of a TRF2-like telomere-binding protein in ArabidopsisSemantic proximity Read ↗

ZNF524 directly interacts with telomeric DNA and supports telomere integritySemantic proximity Read ↗

Dynamics of Protein Binding to Telomeres in Living Cells: Implications for Telomere Structure and FunctionSemantic proximity Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

Control of telomere length by the human telomeric protein TRF1.Semantic proximity Read ↗

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