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Article

Asbestos-induced apoptosis is protein kinase C delta-dependent.

American journal of respiratory cell and molecular biology - 1 Aug 2003

Shukla Arti, Stern Maria, Lounsbury Karen M, Flanders Trisha, Mossman Brooke T

Abstract excerpt

Alveolar epithelial and mesothelial cells undergo apoptosis in response to asbestos, a phenomenon that may be important in injury and/or initiation of compensatory proliferation. Here, we report a functional role of protein kinase (PKC)delta in apoptosis by crocidolite asbestos. We first show that asbestos increases the kinase activity of PKC delta in alveolar type II epithelial cells (C10 line) and causes its...

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Identifiers

PMID: 12626342
DOI: 10.1165/rcmb.2002-0248OC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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